Research & science supports Marodyne LiV

Solid, scientific experience and substantiated results

The Marodyne LiV product draws on a solid, medical foundation. Known globally as the only provider of a fully medically certified (under the EU Medical Devices Directive), safe Low intensity Vibration (LiV) platform, Marodyne is supervised by a scientific advisory board with leading experts from the fields of bio medicine, orthopaedics, osteoporosis, metabolism, rehabilitation medicine and stem cell research. The starting points for the development of the treatment were orthopaedics, osteoporosis and space medicine: the future of the research is increasingly determined by new studies and findings from the field of stem cell biology.

Professor Rubin serves as the Chief Scientific Officer at Marodyne LiV. He is also SUNY Distinguished Professor and Chair of the Department of Biomedical Engineering at the State University of New York at Stony Brook, and Director of the NYSTAR Center for Advanced Technology in Medical Biotechnology.

His work is targeted towards understanding the cellular mechanisms responsible for the growth, healing and homeostasis of musculoskeletal tissues such as bone, cartilage, tendon, ligament and muscle, as well as the formation of adipose tissue (fat). [Remark: Homeostasis can be defined as a property of an organism or system that helps it maintain its parameters within a normal range of values – it is key to life] More specifically, this work focuses on how bio-mechanical stimuli mediate these responses through the control of mesenchymal stem cell differentiation and proliferation. The clinical significance of this work is applicable to the inhibition and reversal of loss of bone mass and bone density, osteopenia and osteoporosis, the promotion of bony ingrowth into implants, the acceleration of fracture healing, and the suppression of obesity and diabetes. Professor Rubin has published over 200 peer-reviewed papers and 50 book chapters on the use of physical stimuli in controlling physiological processes and the musculoskeletal system.

Professor Rubin is a fellow of the American Institute of Biological and Medical Engineers and a recipient of the Presidential Young Investigator Award from the National Science Foundation, two Kappa Delta Awards from the American Academy of Orthopaedic Surgeons, the John Charnley Award from the Hip Society, the Fuller Albright Award from the American Society of Bone and Mineral Research and the Giovanni Borelli Award from the American Society of Biomechanics.

Read more in the new scientific report from June 10, 2020 in Nature Research Journal:
Low Intensity Vibrations Augment Mesenchymal Stem Cell Proliferation and Differentiation Capacity during in vitro Expansion

Bas, G., Loisate, S., Hudon, S.F. et al.

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