Safe & effective treatment

Safe & effective treatment

Marodyne LiV (low intensity vibration) the latest treatment that is medically approved for safe and effective treatment of osteoporosis, muscle weakness (sarcopenia) and other disorders where muscle strength e.g. for fall prevention is compromised. By addressing osteoporosis and muscle weakness, Marodyne LiV can assist in falls prevention – by addressing muscle weakness and nerve disorders, Marodyne LiV can help improve mobility.

Safe solution with no side-effects

Low intensity vibration treatment with Marodyne LiV improves the bone structure naturally and without medication, it stimulates the body’s natural bone-building function – even in cases of osteoporosis. This positive effect has been described in a large number of studies researching how cells respond to low intensity vibration. While a 0.4g acceleration does not feel like much to an individual, it is a strong signal to an individual cell. Mesenchymal stem cells (MSCs) are an adult stem cell population primarily found in the bone marrow, these cells are able to differentiate into various cell types, including bone cells (osteoblasts), fat cells (adipocytes), fibroblasts (collagen), cartilage cells (chondrocytes), and muscle cells (myocytes). Research highlights the therapeutic potential of MSCs and mechanical control of stem cell growth and differentiation is what makes low intensity vibration applicable to many different conditions.

Fundamental differences between low intensity vibration & high intensity vibration

According to research focused on low intensity vibration, there is a small therapeutic window where mechanical signals are effective without putting you at risk. The delivered signal has to be just right: too little or too much stimulus are both equally ineffective as therapies.

Human tolerance limits for vibration

The low intensity vibration signal provided by Marodyne LiV is categorised as safe for daily use at a threshold level of up to 4 hours in relation to the human vibration tolerance by the International Safety Organisation. The below graph is from ISO 2631 Mechanical vibration and shock — evaluation of human exposure to whole-body vibration, and highlights the potential dangers of WBV when compared to the gentle and safe LIV.

 

10 minutes for your health

Several decades of research have shown that low intensity vibration can provide a safe alternative to drugs. Bone is grown, muscles are stimulated, circulation is increased and balance and mobility are improved. To get optimum benefit of this natural and side-effect free therapy the Marodyne LiV should be used daily.

Benefits of Marodyne LiV

Marodyne LiV is safe and usable by anyone – elderly, untrained, children, unconditioned, injured, disabled, or as a preventive measure by the fit & healthy.

Indications for use

– Safe and effective treatment of osteoporosis
– Maintaining and increasing bone mineral density (BMD)
– Building muscle strength & muscle mass in the legs
– Stimulate blood circulation & lymphatic flow
– Improve balance, postural and co-ordination
– No side-effects
– Meets all safety requirements of ISO 2631: mechanical vibration

Bone responds to both large low frequency and small high frequency forces, these forces enable bone to grow and stay healthy. The device provides a very precise low level vibration (0.4g) which is transmitted at a high frequency (30Hz) to the person on the device. Precise low intensity vibration mimic the small high frequency forces exerted by muscles onto the bone. This stimulates osteoblast (bone building) activity while inhibiting osteoclast (bone resorption) activity.

Research has shown that low intensity vibration delivers mechanical signals to the skeleton. A one year placebo-controlled research study of postmenopausal women demonstrated that low-level vibration effectively inhibit bone loss in the spine and femur.

Another study showed that short bouts of LIV increased bone and muscle mass in the weight-bearing skeleton of young adult females with low BMD.

A third study in a large group of women over 60 years or age showed a significant reduction in falls and fractures in the group that used LIV compared to a normal exercise group. Based on these scientific findings and other research the LIV device has been developed as a non-drug treatment to fight osteoporosis.

 

References

Rubin C, Recker R, Cullen D, Ryaby J, McCabe J, McLeod K; Prevention of postmenopausal bone loss by a low-magnitude, high-frequency mechanical stimuli: a clinical trial assessing compliance, efficacy, and safety. Journal of Bone and Mineral Research (2004)

Gilsanz V, Wren T, Sanchez M, Dorey F, Judex S, & Rubin C; Low-Level, High-Frequency Mechanical Signals Enhance Musculoskeletal Development of Young Women With Low BMD. Journal of Bone and Mineral Research (2006)

Rubin C, Capilla E, Luu YK, Busa B, Crawford H, Nolan DJ, Mittal V, Rosen CJ, Pessin JE, Judex S; Adipogenesis is inhibited by brief, daily exposure to highfrequency, extremely lowmagnitude mechanical signals. PNAS – Proceedings of the National Academy of Sciences (2007)

Ozcivici E, Luu YK, Adler B, Qin YX, Rubin J, Judex S, Rubin C; Mechanical signals as anabolic agents in bone. Nature Reviews. Rheumatology (2010)

Muir J, Kiel D, Rubin C; Safety and severity of accelerations delivered from whole body vibration exercise devices to standing adults. Journal of Science and Medicine in Sport (2013)

Pagnotti G, Styner M, Uzer G, Patel V, Wright L, Ness K, Guise ,T Rubin J, Rubin C; Combating osteoporosis and obesity with exercise: leveraging cell mechanosensitivity. Nature Reviews Endocrinology (2019)

Thompson W, Yen S, Rubin J; Vibration therapy. Current Opinion in Endocrinology & Diabetes and Obesity (2014)