Studies

Message from Clinton Rubin

I have spent the entire 35 years of my scientific career trying to understand how mechanical signals influence the body. One of our key findings has been that extremely low magnitude mechanical signals, delivered in the form of Low-intensity Vibration (LiV), have the capacity to dictate the regeneration patterns of mesenchymal stem cells (MSCs) found within the body to stimulate bone and muscle and suppress the formation of fat.

We have discovered, through our many years of scientific research, that Low-intensity Vibration promotes the building of lean muscle mass and the conditioning of muscle reflexes. It is the goal of all biomedical scientists to see the work that we do in the laboratory translate to the clinic, to help the health and well-being of patients. It is very exciting, indeed, that we are finally achieving this goal. Thank you for considering the LiV therapy as a means of restoring and protecting bone and muscle. It has been a long scientific journey, but we are very, very pleased to see the application of this technology become a reality.

Best Regards,

 

Studies related to LiV

Peer-reviewed studies have been featured in leading scientific journals. The journal articles have served as the foundation to build a case solution for diseases such as osteoporosis.

Mechanical signals promote bone and muscle anabolism while limiting formation and expansion of fat mass. Mechanical signals, such as those induced through low-intensity vibration, need not be large in magnitude, or long in duration, to influence bone or fat phenotypes Gabriel M. Pagnotti, Maya Styner, Gunes Uzer, Vihitaben S. Patel, Laura E. Wright, Kirsten K. Ness, Theresa A. Guise, Janet Rubin & Clinton T. Rubin. Combating osteoporosis and obesity with exercise: leveraging cell mechanosensitivity. Nature Reviews Endocrinology (2019)

LiV signals help childhood cancer survivors with bone density Kirsten K. Ness, The effects of low magnitude high frequency mechanical stimulation (LMS) on bone density in childhood cancer survivors (CCS), Podium Presentation, APTA CSM Indianapolis Feb 2015

LiV signals may prevent osteoporosis Ward, K. et al. Low magnitude mechanical loading is osteogenic in children with disabling conditions. J. Bone Miner. Res. 19, 360-369 (2004). DOI: 10.1359/JBMR.040129

LiV signals strengthen long bone Rubin, C., Turner, S. Bain, S., Mallinckrodt, C. & McLeod, K. (2001) Anabolism: Low mechanical signals strengthen long bones. Nature 412:603-604. DOI: 10.1093/ageing/afl082

LiV signals can improve postural stability Jesse Muir, Stefan Judex, Yi-Xian Qin, Clinton Rubin: Postural instability caused by extended bed rest is alleviated by brief daily exposure to low magnitude mechanical signals Gait & Posture 33 (2011) 429–435

LiV signals accelerate and augment bone repair Goodship AE, Lawes TJ, Rubin CT.: Low-magnitude high-frequency mechanical signals accelerate and augment endochondral bone repair: preliminary evidence of efficacy. J Orthop Res. 2009 Jul;27(7):922-30

LiV signals can improve bony ingrowth of implants Rubin, McLeod – Promotion of Bony Ingrowth by Frequency-Specific, Low-Amplitude Mechanical Strain – 1994 Clin Orthop Relat Res.

LiV signals can help to reduce low back pain Holguin N, Muir J, Rubin C, Judex S (2009) Short applications of very low-magnitude vibrations attenuate expansion of the intervertebral disc during extended bed rest. doi:10.1016/j.spine.2009.02.009 in press.

LiV signals have ability to alter mesenchymal stem cells Rubin, C., Capilla, E., Luu, Y-K, Busa, B., Rosen, C., Pessin, J. & Judex, S. (2007). Adipogenesis is suppressed by brief, daily exposure to high frequency, extremely low magnitude mechanical signals. Proc. Nat. Acad. Sci. 104:17879-17884

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